Dynamic metal coordination controls chemoselectivity in radical halogenases
Elijah N. Kissman, Ioannis Kipouros, Jeffrey W. Slater, Elizabeth A. Stone, Avery Y. Yang, Augustin Braun, Alder R. Ensberg, Andrew M. Whitten, Kuntal Chatterjee, Isabel Bogacz, Junko Yano, Joseph Martin Bollinger Jr., Michelle C. Y. Chang
This study shows that dynamic metal coordination and a minimal hydrogen-bond network control chemoselectivity in radical halogenases.
Nature Chemical Biology · Nov 21, 2025Peer-reviewedBiochemistry