Michelle C. Y. Chang

This study shows that dynamic metal coordination and a minimal hydrogen-bond network control chemoselectivity in radical halogenases.

The paper discovers the biosynthetic pathway for the non-canonical amino acid pazamine, involving a radical halogenase and a PLP-dependent enzyme, and shows its potential agricultural applications.

This study engineered microbial strains to produce three C4 chemicals with ~95% theoretical yield by altering gene loci that control carbon flow.

This paper demonstrates a hybrid cellular-heterogeneous catalytic strategy to produce olefins from glucose using engineered microbial strains and catalysts.

This paper describes engineering a fluorine-selective enzyme to produce fluorinated polyketide analogs using E. coli.