Discovery and mechanistic characterization of a probiotic-origin 3β-OH-Δ5-6-cholesterol-5β-reductase directly converting cholesterol to coprostanol
Urmila Netter, Vishakha Bisht, Amit Gaurav, Rekha Sharma, Avik Ghosh, Vinod Singh Bisht, Kiran Ambatipudi, Hanuman Prasad Sharma, Sujata Mohanty, Shubham Loat, Mihir Sarkar, Kapil Tahlan, Naveen Kumar Navani
This paper identifies a probiotic enzyme that converts cholesterol to coprostanol and links its abundance to diabetes.
FEBS Journal · May 13, 2025Peer-reviewedMolecular Biology