Discovery of a Selective Inhibitor of ZIP14 with Therapeutic Potential for Cancer-associated Cachexia
Takafumi Hara, Gen Tanaka, Tomonori Tamura, Masaomi Terajima, Kengo Hamamura, Yuya Yoshida, Tohru Kimura, Yusuke Kasai, Yuta Nakayama, Takumi Umeyama, Kohei Hosoi, Ayaka Noguchi, Yasuno Nakai, Atsushi Hijikata, Koji Matsukawa, , Toshiyuki Fukada
This paper identifies PPTD, the first selective ZIP14 inhibitor, showing it reverses ZIP14-driven cytotoxicity and ameliorates cancer cachexia in mice.
bioRxiv · Oct 23, 2025 · PreprintBiochemistry