Amino acid homorepeats act as buffers to maintain proteostasis and constrain the compatible sequence space of proteomes
Yukihiro Murase, Naoki Kitamura, Shotaro Namba, Ayano Satoh, Takashi T Makino, Ayako Moriya, Hisao Moriya
The paper evaluates the neutrality of amino acid homorepeats in yeast, finding hydrophobic repeats are harmful while hydrophilic repeats suppress proteotoxic stress and define compatible sequence space.
bioRxiv · Jan 22, 2026 · PreprintSystems Biology