The structural influence of the oncogenic driver mutation N642H in the STAT5B SH2 domain
Liam I. Haas-Neill, Deniz Meneksedag‐Erol, Ayesha Chaudhry, Masha Novoselova, Qirat F. Ashraf, Elvin D. de Araujo, Derek J. Wilson, Sarah Rauscher
This study investigates how the N642H mutation in STAT5B stabilizes the parallel dimer through changes in hydrogen bonding, using molecular dynamics simulations and HDX mass spectrometry.
Protein Science · Dec 26, 2024Peer-reviewedBiophysics