Derek J. Wilson

Chemically induced USP21-KLHL12 association recruits USP21 to COPII assembly

The paper shows that BAY-805 induces USP21-KLHL12 association, recruiting USP21 to COPII vesicles and impairing large cargo transport.

Resolving symmetry-masked allosteric cooperativity in the M. tuberculosis proteasome core particle

This paper demonstrates positive cooperativity between subunits in the M. tuberculosis 20S proteasome core particle by using a hybrid subunit assembly and isotopic-coding strategy to resolve symmetry-masked allostery.

Macrocyclic Peptide Tools for Huntingtin-bound HAP40

The paper develops macrocyclic peptides that target HAP40, enabling the study of HTT-HAP40 interactions and their role in Huntington's disease.

Identification and Characterization of a Small Molecule Ligand for the Huntingtin-HAP40 Complex

The paper identifies a small molecule ligand for the HTT-HAP40 complex using AS-MS and validates its binding through multiple techniques, highlighting a druggable interface for HD therapeutics.

High-Affinity, Structure-Validated and Selective Macrocyclic Peptide Tools for Chemical Biology Studies of Huntingtin

This paper identifies and characterizes high-affinity, selective macrocyclic peptide ligands for Huntingtin, enabling structural and functional studies of HTT and its complex with HAP40.

Allostery links hACE2 binding, pan-variant neutralisation and helical extension in the SARS-CoV-2 Spike protein

This paper shows that the antibody ICO-hu104 neutralizes SARS-CoV-2 by causing allosteric changes in the HR1 domain, leading to destabilization of helices and impairing viral fusion.

The structural influence of the oncogenic driver mutation N642H in the STAT5B SH2 domain

This study investigates how the N642H mutation in STAT5B stabilizes the parallel dimer through changes in hydrogen bonding, using molecular dynamics simulations and HDX mass spectrometry.

Innate Conformational Dynamics Drive Binding Specificity in Anti-Apoptotic Proteins Mcl-1 and Bcl-2

This study uses hydrogen deuterium exchange mass spectrometry to show that Mcl-1's binding specificity arises from dynamic modes in its unbound state, distinct from Bcl-2.