L-type channel voltage-dependent facilitation results from asymmetric π-H and π-π quadrangle interactions at DI-DII domains
Aynal Hoque, Vishal Tanaji Khade, EDE Venkata Gopal, Abhijeet Sudhir Kate, Gerald Werner Zamponi, Giriraj Sahu
This study identifies asymmetric π-H and π-π quadrangle interactions at the DI-DII interface of L-type channels as the molecular basis for voltage-dependent facilitation.
bioRxiv · Oct 5, 2026 · PreprintBiophysics