Hereditary Pancreatitis Model by Blastocyst Complementation in Mouse
Ayumu Asai, Masamitsu Konno, Jun Koseki, Koichi Kawamoto, Takahiro Arai, Taroh Satoh, Hidetoshi Eguchi, Masaki Mori, Yuichiro Doki, Hideshi Ishii
This study uses blastocyst complementation to model human hereditary pancreatitis in mice, showing that PRSS1 mutations lead to trypsin activation, mimicking the human disease phenotype.
Oncotarget · Jun 2, 2020Peer-reviewedDevelopmental Biology