Author

Jun Koseki

Cellular and Molecular Biotechnology Research InstituteORCID 0000-0002-6473-4076Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Ayumu Asai· 1 shared Chie MotonoiD· 1 shared Genki KudoiD· 1 shared Hideshi IshiiiD· 1 shared Hidetoshi EguchiiD· 1 shared Keisuke YanagisawaiD· 1 shared Kenichiro ImaiiD· 1 shared Koichi KawamotoiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperDevelopmental Biology

Ayumu Asai

Mutual co-authors in cluster

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2 papers

Recent·Most cited

CrypToth: Cryptic pocket detection through mixed-solvent molecular dynamics simulations based topological data analysis

Jun Koseki, Chie Motono, Keisuke Yanagisawa, Genki Kudo, Ryunosuke Yoshino, Takatsugu Hirokawa, Kenichiro Imai

CrypToth identifies cryptic sites on proteins using mixed-solvent molecular dynamics and topological data analysis, achieving high accuracy in hotspot prediction.

Journal of Chemical Information and Modeling · May 22, 2025Peer-reviewedBioinformatics

Hereditary Pancreatitis Model by Blastocyst Complementation in Mouse

Ayumu Asai, Masamitsu Konno, Jun Koseki, Koichi Kawamoto, Takahiro Arai, Taroh Satoh, Hidetoshi Eguchi, Masaki Mori, Yuichiro Doki, Hideshi Ishii

This study uses blastocyst complementation to model human hereditary pancreatitis in mice, showing that PRSS1 mutations lead to trypsin activation, mimicking the human disease phenotype.

Oncotarget · Jun 2, 2020Peer-reviewedDevelopmental Biology