A spatial atlas of chemoradiation therapy in pancreatic cancer identifies cellular and microenvironmental determinants of persister populations
Vincent Bernard, Li-Ting Ku, Tianyu Wang, Ariana Acevedo-Diaz, Kimal Rajapakshe, Galia Jacobson, Daniela Tovar, Jimin Min, Guangsheng Pei, Candise L. Tat, Ayush Suresh, Ching-Wei David Tzeng, Matthew H. G. Katz, Manoop S. Bhutani, Huaming Wang, , Eugene Jon Koay
This study identifies cellular and microenvironmental factors contributing to radiation therapy resistance in pancreatic cancer using spatial transcriptomics and single-cell RNA sequencing.
bioRxiv · Jun 20, 2025 · PreprintCancer Biology