Albert C. Koong

This study shows that Th2-polarized CD4+ T-cells drive TNBC recurrence through TGFβ-induced pro-invasive signaling in irradiated mammary tissue.

This study shows that combining stereotactic body radiation therapy with KRAS inhibition synergistically improves preclinical pancreatic cancer treatment by enhancing tumor control and reducing recurrence.

This study investigates how FLASH and conventional radiation affect mitochondrial function in tumor and nontumorigenic cells, finding FLASH preserves mitochondrial integrity in non-tumor cells.

This study shows FLASH radiotherapy reduces lymphocyte apoptosis and prevents immunosuppression by modulating the Chk1-STAT3 pathway in a preclinical model.

This study identifies cellular and microenvironmental factors contributing to radiation therapy resistance in pancreatic cancer using spatial transcriptomics and single-cell RNA sequencing.

This study compares acute gastrointestinal toxicity from synchrotron-based proton and linac-based electron ultra-high dose rate irradiation in mice, finding higher toxicity with proton FLASH compared to conventional and electron treatments.

This study evaluates how varying radiation beam parameters affect gastrointestinal toxicity and tumor response in mice, finding that high dose per pulse and ultra-high dose rate independently reduce toxicity while maintaining tumor control.