CRISPRa screen identifies a role for c-KIT signaling in tamoxifen resistance, potentially through upregulation of ABC transporters
B. A. Marks, L. A. Choate, K. Sams, L. Zhu, G. Waidyaratne, C. G. Danko, S. A. Coonrod
This study uses a CRISPRa screen to identify c-KIT signaling as a contributor to tamoxifen resistance in ER+ breast cancer, potentially through upregulation of ABC transporters.
bioRxiv · Aug 22, 2022 · PreprintCancer Biology