Author

C. G. Danko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Evolutionary Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

E. J. Rice· 4 shared P. Sethupathy· 3 shared A. C. Vill· 2 shared F. C. Pan· 2 shared I. L. Brito· 2 shared J. J. Lewis· 2 shared J. W. Villanueva· 2 shared M. Kanke· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersCancer Biology

E. J. Rice

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Author profile →

8 papers

Recent·Most cited

Multi-omic study of genome-edited human colonoid models of colorectal cancer reveal genotype-specific patterns of microRNA regulation

J. W. Villanueva, F. C. Pan, E. J. Rice, Y.-H. Hung, M. Winnicki, S. Chen, C. G. Danko, P. Sethupathy

This study uses genome-edited human colonoids to identify genotype-specific miRNA regulation patterns in colorectal cancer, highlighting potential therapeutic targets.

bioRxiv · Jul 28, 2023 · PreprintCancer Biology

Evolution of promoter-proximal pausing enabled a new layer of transcription control

A. G. Chivu, B. A. Basso, A. Abuhashem, M. M. Leger, G. Barshad, E. J. Rice, A. C. Vill, W. Wong, S.-P. Chou, G. Chovatiya, R. Brady, J. Smith, A. Wikramanayake, C. Arenas-Mena, I. L. Brito, , C. G. Danko

The paper investigates the evolutionary emergence of RNA polymerase II pausing and its regulatory role across species.

bioRxiv · Feb 19, 2023Evolutionary Biology

CRISPRa screen identifies a role for c-KIT signaling in tamoxifen resistance, potentially through upregulation of ABC transporters

B. A. Marks, L. A. Choate, K. Sams, L. Zhu, G. Waidyaratne, C. G. Danko, S. A. Coonrod

This study uses a CRISPRa screen to identify c-KIT signaling as a contributor to tamoxifen resistance in ER+ breast cancer, potentially through upregulation of ABC transporters.

bioRxiv · Aug 22, 2022 · PreprintCancer Biology

Run-on sequencing reveals nascent transcriptomics of the human microbiome

A. C. Vill, C. G. Danko, E. J. Rice, I. De Vlaminck, I. L. Brito

This study applies PRO-seq to the human microbiome to profile nascent transcription, revealing taxon-specific RNAP pause motifs and concurrent transcription and cleavage of guide RNAs and tRNA fragments.

bioRxiv · Apr 22, 2022 · PreprintMicrobiology

Genome edited colorectal cancer organoid models reveal distinct microRNA activity patterns across different mutation profiles

J. W. Villanueva, L. Kwong, T. Han, S. A. Martinez, F. C. Pan, M. T. Shanahan, M. Kanke, S. Chen, L. E. Dow, C. G. Danko, P. Sethupathy

The paper uses genome-edited colorectal cancer organoids to identify microRNA expression patterns linked to specific mutation profiles and shows miR-24-3p's role in promoting cancer cell survival.

bioRxiv · Dec 13, 2021 · PreprintCancer Biology

Chromosome fusion affects genetic diversity and evolutionary turnover of functional loci, but consistently depends on chromosome size

F. Cicconardi, J. J. Lewis, S. H. Martin, R. D. Reed, C. G. Danko, S. H. Montgomery

This study examines how chromosome fusions in Heliconius butterflies affect genetic diversity and functional locus turnover, showing size-dependent evolutionary impacts.

bioRxiv · Jan 6, 2021Evolutionary Biology

Hotspots of aberrant enhancer activity in fibrolamellar carcinoma reveal molecular mechanisms of oncogenesis and intrinsic drug resistance

T. A. Dinh, R. Sritharan, F. D. Smith, A. B. Francisco, R. K. Ma, R. P. Bunaciu, M. Kanke, C. G. Danko, A. P. Massa, J. D. Scott, P. Sethupathy

This study identifies aberrant enhancer activity in fibrolamellar carcinoma, revealing molecular mechanisms of oncogenesis and drug resistance, and suggests new therapeutic targets.

bioRxiv · Jan 18, 2020 · PreprintCancer Biology

ER-positive breast cancer cells are poised for RET-mediated endocrine resistance

S. Horibata, E. J. Rice, H. Zheng, L. J. Anguish, S. Coonrod, C. G. Danko

This study shows that ER+ breast cancer cells have the RET signaling pathway components but lack RET ligands needed for endocrine resistance, linking RET ligand expression to therapy response and survival.

bioRxiv · Sep 21, 2017Cancer Biology