L. Zhu

Renal Proximal Tubule Cell-specific Megalin Deletion Does Not Affect Atherosclerosis But Induces Tubulointerstitial Nephritis in Mice Fed Western Diet

This study shows that deleting megalin in renal proximal tubule cells does not reduce atherosclerosis but causes tubulointerstitial nephritis in male mice fed a Western diet.

CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies

The paper shows CD4 downregulation precedes Env expression in HIV-1-infected cells, making them resistant to non-neutralizing antibody-mediated ADCC.

Plant Accessible Tissue Clearing Solvent System (PATCSOS) for 3-D Imaging of Whole Plants

The paper introduces PATCSOS, a new plant tissue clearing method enabling 3-D imaging of whole plants, including Arabidopsis tissues and other species, with high efficiency and compatibility with fluorescence imaging.

Structural plasticity of 2A proteins in the Parechovirus family

The paper investigates structural plasticity in Parechovirus 2A proteins, revealing structural rearrangements that affect their oligomeric state and potential function in viral RNA replication.

Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

This study shows that Piezo1 in intestinal L cells mechanically regulates GLP-1 production, affecting glucose tolerance and diabetes.

BET inhibition induces GDH1-dependent glutamine metabolic remodeling and vulnerability in liver cancer

This study shows BET inhibition in liver cancer reduces proliferation by inducing GDH1-dependent glutamine metabolic changes, suggesting a therapeutic strategy combining BET and OXPHOS inhibitors.

Unexpected transformations during pyrroloiminoquinone biosynthesis

This study reveals the complexity of pyrroloiminoquinone biosynthesis by identifying four additional enzymes that correct a previously proposed pathway and show that amino groups come from glycine, asparagine, and leucine.

Structural insights into sphingosine 1-phosphate receptor 4 activation

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.

HKDC1 Promotes Liver Cancer Stemness Under Hypoxia via Stabilizing β-Catenin

This study identifies HKDC1 as a prometastatic enzyme in liver cancer that stabilizes β-catenin under hypoxia, enhancing cancer stemness.

Modeling gene-environment interactions in Parkinson's Disease: Helicobacter pylori infection of Pink1-/- mice induces CD8 T cell-dependent motor and cognitive dysfunction.

This study shows that Helicobacter pylori infection in Pink1-/- mice causes motor and cognitive dysfunction linked to CD8 T cell activity, mimicking early PD features.

Enhanced microbiota profiling in patients with quiescent Crohn's disease through comparison with paired healthy first-degree relatives using fecal metagenomics and metabolomics

The paper compares microbiota and metabolome profiles of quiescent Crohn's disease patients with their healthy first-degree relatives to identify biomarkers associated with disease relapse.

The first discovery of SFTSV in the Centre of Metropolitan Beijing, China

This study identifies SFTSV circulation in central Beijing by surveying ticks and hedgehogs, revealing high seroprevalence and RNA prevalence in urban areas.

Gut microbial-mediated polyphenol metabolism is restrained by parasitic whipworm infection and associated with altered immune function in mice

This study shows that polyphenol intake interacts with parasitic whipworm infection in mice, altering immune responses and gut microbial metabolism.

Germinal center BCR maturation in appendicitis reveals a role for antigen-specific adaptive immune responses during disease

This study identifies antigen-dependent B cell activation and microbial dysbiosis in appendicitis, linking immune and microbial factors to disease pathology.

An Efficient and Safe Trans-complementation System for MPXV Mimicking Authentic Viral Infection

This paper develops a safe trans-complementation system for MPXV that mimics authentic infection, enabling research in lower biosafety labs without live virus.

Cryo-EM structure of monomeric CXCL12-bound CXCR4 in active state

This paper presents a cryo-EM structure of CXCL12-bound CXCR4 in an active state, revealing key interactions that stabilize the ligand-receptor complex.

Population size interacts with reproductive longevity to shape the germline mutation rate

The paper examines how reproductive longevity interacts with population size to shape germline mutation rates, finding that longer reproductive ages reduce mutation rates per year in sperm and eggs.

High-Throughput Evolution Unravels Landscapes of High-Level Antibiotic Resistance Induced by Low-Level Antibiotic Exposure

This study uses high-throughput evolution to explore antibiotic resistance landscapes in E. coli exposed to low-level antibiotics, identifying key mutations and developing predictive models.

High-fidelity, generalizable light-field reconstruction of biological dynamics with physics-informed meta neural representation

This paper introduces LFMNR, a method for high-fidelity 3D reconstruction of biological dynamics using physics-informed neural representations and meta-learning, achieving improved resolution and speed.

Microbiome-based correction for random errors in nutrient profiles derived from self-reported dietary assessments

This study introduces METRIC, a deep-learning method that uses gut microbiome data to correct random errors in self-reported dietary assessments, showing effectiveness in simulated and real-world datasets.

Ultra-Long-Term Delivery of Hydrophilic Drugs Using Injectable In Situ Cross-Linked Depots

This paper develops an injectable platform for ultra-long-term hydrophilic drug delivery, achieving sustained release over six months in vivo.

Structural Insights into Dopamine Receptor-Ligand Interactions: From Agonists to Antagonists

This study investigates dopamine receptor-ligand interactions using molecular modeling, revealing binding modes and stability of agonists and antagonists at D1R and D5R.

An immunohistochemical atlas of necroptotic pathway expression

The paper develops automated immunohistochemistry protocols to detect necroptotic pathway proteins in mouse and human tissues, revealing heterogeneity and disease-related changes in expression.

Discovery of biaryl macrocyclic peptides with C-terminal β-amino-α-keto acid groups

This study discovers a new class of macrocyclic peptides by mining genomes for biosynthetic gene clusters, revealing novel enzymatic modifications involving a cytochrome P450 and other enzymes.

Neuroprotective Mechanism of Ribisin A on H 2 O 2 -induced PC12 cell injury model

This study investigates how Ribisin A protects PC12 cells from H2O2-induced injury by enhancing antioxidant activity, reducing inflammation, and modulating the ERK/CREB signaling pathway.

Diet composition drives tissue-specific intensity of murine enteric infections

This study shows that diet composition affects tissue-specific susceptibility to enteric infections in mice, with fiber-rich diets increasing pathogen burden in some cases.

Logic Gate Activated Lysosome Targeting DNA Nanodevice for Controlled Proteins Degradation

This paper develops a logic-gate activated lysosome targeting DNA nanodevice for controlled protein degradation and modulates T cell-mediated antitumor immunity.

PRO-LDM: Protein Sequence Generation with a Conditional Latent Diffusion Model

PRO-LDM generates protein sequences with tailored properties using a conditional latent diffusion model, enhancing diversity and design fidelity.

Semantic redundancy-aware implicit neural compression for multidimensional biomedical image data

This paper introduces SINCS, a compression method for multidimensional biomedical images that improves efficiency and quality by leveraging semantic redundancy and saliency maps.

Host-microbiota interactions contributing to the heterogeneous tumor microenvironment in colorectal cancer

The paper identifies host-microbiota interactions in colorectal cancer subtypes, revealing distinct gene-microbe associations that contribute to tumor microenvironment heterogeneity.