Prevention of Drug-Induced Lung Fibrosis via Inhibition of the MRTF/SRF Transcription Pathway
K. Pawelec, M. Varnum, J. R. Harkema, B. Auerbach, S. D. Larsen, R. R. Neubig
This study shows that inhibiting the MRTF/SRF pathway with CCG-257081 prevents drug-induced lung fibrosis in mice, outperforming standard treatments in reducing fibrosis markers.
bioRxiv · Sep 9, 2021Pharmacology & Toxicology