Bruton's Tyrosine Kinase Supports Gut Mucosal Immunity and Commensal Microbiome Recognition in Autoimmune Arthritis
R. H. Bonami, C. E. Thurman, L. E. Nyhoff, C. S. Westlake, B. B. Barron, P. L. Kendall
This study shows Btk deficiency reduces intestinal IgA and alters the microbiome, leading to reduced arthritis in K/BxN mice.
bioRxiv · Mar 10, 2021Immunology