Proteasomal Inhibition Triggers Viral Oncoprotein Degradation via Autophagy-Lysosomal Pathway
C. Gain, S. Malik, S. Bhattacharjee, A. Ghosh, E. S. Robertson, B. B. Das, A. Saha
This study shows proteasomal inhibition causes degradation of EBNA3A and EBNA3C viral oncoproteins via autophagy-lysosomal pathway, while EBNA3B remains stable, suggesting potential therapeutic use of proteasome inhibitors for EBV-related B-cell lymphomas.
bioRxiv · Sep 23, 2019Cancer Biology