Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis
C. L. Grandjean, Z. Garcia, F. Lemaitre, B. Breart, P. Bousso
This study uses intravital imaging to show that antibody-dependent phagocytosis by bone marrow macrophages is the main mechanism of anti-CD20 therapy, but its efficiency is limited by time and spatial constraints.
bioRxiv · May 26, 2020Immunology