Identification of two principal amyloid-driving segments in variable domains of Ig light chains in AL amyloidosis
B. Brumshtein, S. Esswein, M. R. Sawaya, A. T. Ly, M. Landau, D. S. Eisenberg
The paper identifies two independent amyloid-driving segments in Ig light chain variable domains that drive fibril formation in AL amyloidosis and are potential therapeutic targets.
bioRxiv · Jun 26, 2018Biochemistry