Structural insights into the interaction of heme with protein tyrosine kinase JAK2
B. F. Schmalohr, A.-H. M. Mustafa, O. Krämer, D. Imhof
The paper shows heme induces hyperphosphorylation of JAK2 via specific motifs in its kinase domain, suggesting potential for heme-related pharmacological tools in myeloproliferative disorders.
bioRxiv · Aug 13, 2020Biochemistry