Tumors escape immunosurveillance by overexpressing the proteasome activator REGγ
M. Boulpicante, R. Darrigrand, A. Pierson, V. Salgues, B. Gaudineau, M. Khaled, A. Cattaneo, A. Bachi, P. Cascio, S. Apcher
The paper shows cancer cells evade immunosurveillance by upregulating REGγ, which increases destruction of MHC-I peptides generated from nuclear translation products.
bioRxiv · Jan 6, 2019Immunology