Developmental-stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors
H. P. Singh, S. Wang, K. Stachelek, S. Lee, M. W. Reid, M. E. Thornton, C. M. Craft, B. H. Grubbs, D. Cobrinik
This paper shows that RB1 inactivation leads to retinoblastoma in human cone precursors at specific developmental stages, but not in mouse cone precursors, highlighting species-specific differences in tumor genesis.
bioRxiv · Jun 26, 2018Cancer Biology