Author

B. Kleizen

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. S. Thomas· 1 shared F. M. Peters· 1 shared I. Braakman· 1 shared K. W. Peters· 1 shared L. Kooijman· 1 shared M. K. Grudniewska· 1 shared M. Mijnders· 1 shared M. van Willigen· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

A. S. Thomas

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1 paper

Recent·Most cited

Co-translational folding of the first transmembrane domain of ABC-transporter CFTR is supported by assembly with the first cytosolic domain

B. Kleizen, M. van Willigen, M. Mijnders, F. M. Peters, M. K. Grudniewska, T. M. Hillenaar, A. S. Thomas, L. Kooijman, K. W. Peters, R. Frizzell, P. van der Sluijs, I. Braakman

This study reveals early co-translational folding and assembly of CFTR's TMD1 and ICL1 domains, showing how VX-809 enhances this process and supports CFTR function.

bioRxiv · Dec 19, 2020Biochemistry