Author

P. van der Sluijs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

I. Braakman· 3 shared M. Mijnders· 2 shared M. van Willigen· 2 shared T. Hillenaar· 2 shared A. S. Thomas· 1 shared B. Kleizen· 1 shared F. M. Peters· 1 shared H. Y. Yeoh· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBiochemistry

I. Braakman

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3 papers

Recent·Most cited

Redefining hypo- and hyper-responding phenotypes of CFTR mutants for understanding and therapy.

T. Hillenaar, J. Beekman, P. van der Sluijs, I. Braakman

The paper identifies biochemical and functional characteristics of CFTR mutants that respond poorly or exceptionally well to modulators, informing improved therapeutic strategies.

bioRxiv · Sep 12, 2022Biochemistry

ABC-transporter CFTR folds with high fidelity through a modular, stepwise pathway

J. Im, T. Hillenaar, H. Y. Yeoh, P. Sahasrabudhe, M. Mijnders, M. van Willigen, P. van der Sluijs, I. Braakman

This study reveals the stepwise folding pathway of CFTR, showing two distinct stages of domain folding and assembly, with implications for understanding protein misfolding diseases.

bioRxiv · Jul 20, 2022Biochemistry

Co-translational folding of the first transmembrane domain of ABC-transporter CFTR is supported by assembly with the first cytosolic domain

B. Kleizen, M. van Willigen, M. Mijnders, F. M. Peters, M. K. Grudniewska, T. M. Hillenaar, A. S. Thomas, L. Kooijman, K. W. Peters, R. Frizzell, P. van der Sluijs, I. Braakman

This study reveals early co-translational folding and assembly of CFTR's TMD1 and ICL1 domains, showing how VX-809 enhances this process and supports CFTR function.

bioRxiv · Dec 19, 2020Biochemistry