Analysis of spike protein variants evolved in a novel mouse model of persistent SARS-CoV-2 infection
D. Kim, J. Kim, M. Kim, H. Park, S. Maharjan, K. Baek, B. M. Kang, S. Kim, S. Park, M.-S. Park, Y. Lee, H.-J. Kwon
The paper establishes a novel mouse model of persistent SARS-CoV-2 infection using Calu-3 xenografts and identifies spike protein mutations that enhance viral replication and host adaptation.
bioRxiv · Mar 19, 2023 · PreprintMicrobiology