Phenotypic screening of the ReFrame Drug Repurposing Library to discover new drugs for treating sickle cell disease
B. Metaferia, T. Cellmer, E. B. Dunkerlberger, Q. Li, E. R. Henry, J. Hofrichter, D. Staton, M. M. Hsieh, A. K. Conrey, J. F. Tisdale, A. K. Chatterjee, S. L. Thein, W. A. Eaton
This paper screens a drug repurposing library to identify compounds that inhibit sickling in sickle cell disease, finding 106 potential anti-sickling drugs with 21 predicted to be viable oral therapies.
bioRxiv · Jun 23, 2022Pharmacology & Toxicology