High resolution structure of a partially folded insulin aggregation intermediate
B. N. Ratha, R. K. Kar, J. R. Brender, B. Sahoo, S. Kalita, A. Bhunia
The paper identifies a partially folded insulin intermediate involved in aggregation at acidic pH and describes its structural features that may promote oligomer formation.
bioRxiv · Jul 28, 2019Biophysics