Author

J. R. Brender

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 7 Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:imaging· 7 Organism:mouse· 7 Research Focus:cell type annotation· 5 Research Focus:cancer & tumor microenvironment· 3 Research Focus:differential expression· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

M. C. Krishna· 8 shared K. Yamamoto· 7 shared S. Kishimoto· 7 shared Y. Saida· 5 shared J. B. Mitchell· 4 shared G. V. Chandramouli· 3 shared N. Devasahayam· 3 shared Y. Otowa· 3 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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8 shared papersCancer Biology

M. C. Krishna

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Metabolic and imaging phenotypes associated with RB1 and TP53 loss in prostate cancer

F. Ahmad, M. White, K. Yamamoto, D. R. Crooks, S. Agarwal, Y. Yang, B. Capaldo, S. Raj, A. N. Alilin, A. Ton, S. Adler, J. Seidel, C. Olkowski, M. K. Cherukuri, P. L. Choyke, , J. R. Brender

This study investigates metabolic and imaging phenotypes in prostate cancer linked to RB1 and TP53 loss, finding metabolic changes that may inform multimodal imaging strategies.

bioRxiv · Nov 15, 2023Cancer Biology

Evofosfamide and Gemcitabine Act Synergistically in Pancreatic Cancer Xenografts by Dual Action on Tumor Vasculature and Inhibition of Homologous Recombination DNA Repair

Y. Otowa, S. Kishimoto, Y. Saida, K. Yamashita, K. Yamamoto, G. V. Chandramouli, N. Devasahayam, J. B. Mitchell, M. C. Krishna, J. R. Brender

This study shows that evofosfamide and gemcitabine work together in pancreatic cancer xenografts by improving tumor oxygenation and inhibiting DNA repair, with effects varying by tumor type.

Antioxidants & Redox Signaling · Sep 1, 2023Peer-reviewedCancer Biology

Evaluation of a deuterated triarylmethyl spin probe for in vivo R2*-based EPR oximetric imaging with enhanced dynamic range

S. Kishimoto, N. Devasahayam, G. V. Chandramouli, R. Murugesan, Y. Otowa, K. Yamashita, K. Yamamoto, J. R. Brender, M. C. Krishna

This study compares two spin probes for oxygen measurement in vivo, finding Ox071 more sensitive and capable of a broader pO2 range.

bioRxiv · May 18, 2023Biophysics

PEGPH20, a PEGylated Human Hyaluronidase, Induces Radiosensitization by Reoxygenation In Pancreatic Cancer Xenografts. A Molecular Imaging Study

T. Seki, Y. Saida, S. Kishimoto, J. Lee, Y. Otowa, K. Yamamoto, G. V. Chandramouli, N. Devasahayam, J. B. Mitchell, J. R. Brender, M. C. Krishna

This study shows PEGPH20 improves radiation therapy efficacy in pancreatic cancer tumors with high hyaluronan by increasing oxygenation, as measured by multiple imaging techniques.

bioRxiv · Jan 11, 2022Cancer Biology

Detecting Early Response to Immune Checkpoint Blockade by Multimodal Molecular Imaging

Y. Saida, J. R. Brender, K. Yamamoto, J. B. Mitchell, M. C. Krishna, S. Kishimoto

This study uses multimodal imaging to detect early response to immune checkpoint blockade therapy in tumor models, identifying imaging biomarkers for treatment assessment.

Cancer Research · Jul 1, 2021Peer-reviewedCancer Biology

In vivo deuterated water labeling allows tumor visualization via deuterium magnetic resonance spectroscopic imaging of cholesterol

J. C. Assmann, J. R. Brender, D. E. Farthing, K. Saito, K. A. Warrick, N. Maglakelidze, D. R. Crooks, H. Merkle, M. C. Krishna, R. E. Gress, N. P. Buxbaum

bioRxiv · May 28, 2020 · PreprintCancer Biology

Reoxygenation after Evofosfamide Treatment in Pancreatic Ductal Adenocarcinoma Xenografts is due to Decreased Oxygen Consumption and not Increased Oxygen Supply

S. Kishimoto, j. R. Brender, Y. Saida, K. Yamamoto, J. B. Mitchell, M. C. Krishna

This study shows evofosfamide treatment reduces tumor hypoxia by decreasing oxygen consumption, not increasing oxygen supply, using pO2 imaging in xenograft models.

bioRxiv · May 16, 2020 · PreprintCancer Biology

Trehalose as an alternative to glycerol as a glassing agent for in vivo DNP MRI

J. R. Brender, S. Kishimoto, G. R. Eaton, S. S. Eaton, Y. Saida, M. C. Krishna

This study compares trehalose and glycerol as glassing agents in DNP MRI, finding trehalose provides faster polarization with similar effectiveness and fewer metabolic perturbations.

bioRxiv · Dec 6, 2019Biophysics

High resolution structure of a partially folded insulin aggregation intermediate

B. N. Ratha, R. K. Kar, J. R. Brender, B. Sahoo, S. Kalita, A. Bhunia

The paper identifies a partially folded insulin intermediate involved in aggregation at acidic pH and describes its structural features that may promote oligomer formation.

bioRxiv · Jul 28, 2019Biophysics

Distinguishing Closely Related Pancreatic Cancer Subtypes In Vivo by 13C Glucose MRI without Hyperpolarization

S. Kishimoto, J. R. Brender, S. Matsumoto, T. Seki, N. Oshima, H. Merkle, G. Reed, A. P. Chen, J. H. Ardenkjaer-Larsen, J. Munasinghe, K. Saito, K. Yamamoto, P. Choyke, J. Mitchell, M. C. Krishna

The paper distinguishes closely related pancreatic cancer subtypes in vivo using 13C glucose MRI without hyperpolarization by detecting metabolic differences through tensor decomposition.

bioRxiv · Jan 4, 2019 · PreprintCancer Biology