Evolution-Inspired Engineering of Anthracycline Methyltransferases
P. Dinis, H. Tirkkonen, V. Siitonen, B. Nji Wandi, J. Niemi, T. Grocholski, M. Metsa-Ketela
The paper engineers anthracycline methyltransferases by combining regions from four subfamilies to expand their catalytic capabilities and understand factors influencing substrate specificity and reaction outcomes.
bioRxiv · Aug 5, 2021Biochemistry