Author

M. Metsa-Ketela

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

V. Siitonen· 3 shared A. Akhgari· 2 shared A. Koroleva· 2 shared H. Tirkkonen· 2 shared J. Niemi· 2 shared B. Baral· 1 shared B. Nji Wandi· 1 shared C. E. Melancon· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMicrobiology

V. Siitonen

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Physical interactions trigger Streptomyces to prey on yeast using natural products and lytic enzymes

K. Yamada, A. Koroleva, H. Tirkkonen, V. Siitonen, M. Laughlin, A. Akhgari, G. Mazurier, J. Niemi, M. Metsa-Ketela

This study shows Streptomyces bacteria prey on yeast by producing lytic enzymes and natural products, revealing a new ecological role for these microbes.

bioRxiv · Jun 15, 2023 · PreprintMicrobiology

Single cell mutant selection for metabolic engineering of actinomycetes

A. Akhgari, B. Baral, A. Koroleva, V. Siitonen, D. P. Fewer, C. E. Melancon, J. Rahkila, M. Metsa-Ketela

This paper develops a single-cell sorting method to enhance metabolic engineering in actinomycetes by selecting high-performing mutants for drug discovery and industrial enzyme production.

bioRxiv · Jan 13, 2022Bioengineering

Evolution-Inspired Engineering of Anthracycline Methyltransferases

P. Dinis, H. Tirkkonen, V. Siitonen, B. Nji Wandi, J. Niemi, T. Grocholski, M. Metsa-Ketela

The paper engineers anthracycline methyltransferases by combining regions from four subfamilies to expand their catalytic capabilities and understand factors influencing substrate specificity and reaction outcomes.

bioRxiv · Aug 5, 2021Biochemistry