SARS-CoV-2 E and 3a proteins are inducers of pannexin currents
B. Oliveira Mendes, M. Alameh, B. Ollivier, J. Montnach, N. Bidere, F. Souaze, N. Escriou, F. Charpentier, I. Baro, M. De Waard, G. Loussouarn
This paper investigates whether SARS-CoV-2 E and 3a proteins act as viroporins and finds they instead induce cell shape changes and death, indirectly activating pannexin channels.
bioRxiv · Oct 20, 2022Cell Biology