Short-term oxaliplatin exposure according to established hyperthermic intraperitoneal chemotherapy (HIPEC) protocols lacks effectiveness in vitro and ex vivo
M. W. Löffler, N. Seyfried, M. Burkard, B. Oswald, A. Tolios, C. Yurttas, F. Herster, J. Kauer, T. Jäger, K. Thiel, S. P. Haen, H.-G. Rammensee, S. Venturelli, M. Schwab, A. Königsrainer, S. Beckert
This study shows that oxaliplatin-containing solutions during HIPEC protocols are ineffective in vitro and ex vivo, with low cytotoxicity and cell shrinkage observed.
bioRxiv · Jul 31, 2019 · PreprintPharmacology & Toxicology