B. S. Khatri

Weakly deleterious natural genetic variation greatly amplifies probability of resistance in multiplexed gene drive systems

The paper uses stochastic simulations to show weakly deleterious genetic variants significantly increase resistance probability in multiplexed gene drive systems.

A theory of the dynamics of DNA loop initiation in condensin/cohesin complexes

The paper develops a theory to model DNA loop initiation dynamics in condensin/cohesin complexes, predicting mean first passage times of 1-10 seconds.

Computational and experimental analyses of mitotic chromosome formation pathways in fission yeast

The paper compares loop extrusion and diffusion capture models of SMC complex function in mitotic chromosome formation using simulations and experimental data.

Survival of the frequent at finite population size and mutation rate: bridging the gap between quasispecies and monomorphic regimes with a simple model

This paper derives a phenotype distribution from genotype frequencies under mutation and selection, bridging the gap between quasispecies and monomorphic evolutionary regimes.

Biophysics and population size constrains speciation in an evolutionary model of developmental system drift

This study shows that biophysics and population size strongly constrain speciation in an evolutionary model of developmental system drift, with speciation rates following a power law at small populations and sub-diffusive growth at large ones.

Robust estimation of recent effective population size from number of independent origins in soft sweeps

The paper estimates recent effective population size using the number of independent origins in soft sweeps, showing it is robust to selection strength and provides bounds for demographic changes.