Dysfunctional β-cell longevity in diabetes relies on high energy conservation and positive epistasis
K. H. Raval, N. Jamshidi, B. S. Seyran, L. Salwinski, R. K. Pillai, L. Yang, F. Ma, M. Pellegrini, J. Shin, X. Yang, S. Tudzarova
The paper identifies PFKFB3-expressing dysfunctional β-cells in T2D, showing their survival via positive epistasis and reduced clearance, and demonstrates PFKFB3 inhibition restores glucose tolerance in mice.
bioRxiv · Mar 18, 2024Cell Biology