M. Pellegrini

Genetic and anatomical determinants of olfaction in dogs and wild canids

This study investigates the genetic and anatomical basis of olfaction in dogs and wild canids, finding no evidence of human-directed selection for enhanced olfaction in domestic dogs.

Dysfunctional β-cell longevity in diabetes relies on high energy conservation and positive epistasis

The paper identifies PFKFB3-expressing dysfunctional β-cells in T2D, showing their survival via positive epistasis and reduced clearance, and demonstrates PFKFB3 inhibition restores glucose tolerance in mice.

Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of Phosphodiesterase 2A

This study investigates the role of PDE2A in socio-cognitive deficits by analyzing Pde2a+/- mice, revealing microglia activation and AMPAR trafficking defects linked to cognitive impairments.

mRNA vaccines encoding membrane-anchored receptor-binding domains of SARS-CoV-2 mutants induce strong humoral responses and can overcome immune imprinting

IL-1B-mediated inflammatory signaling drives ineffective erythropoiesis in early-stage myelodysplastic syndromes

This study shows that IL-1B-mediated inflammation drives ineffective erythropoiesis in early-stage MDS and that canakinumab can reduce transfusion dependence in patients with DNMT3A and TET2 mutations.

Barking up the wrong tree: the importance of morphology in plant molecular phylogenetic studies

The paper examines a case where molecular phylogenetic analysis misclassified a plant species due to a sampling error, emphasizing the importance of morphology in phylogenetic studies.

Transcriptional drifts associated with environmental changes in endothelial cells

The paper identifies transcriptional changes in endothelial cells due to environmental factors like shear stress and heterotypic interactions, showing their impact on gene expression independent of genetic background.

Sex differences in NK cells mediated by the X-linked epigenetic regulator UTX

This study identifies UTX as a key X-linked epigenetic regulator causing sex differences in NK cell function, with males showing reduced IFN-γ production despite higher numbers.

Canonical Wnt Signaling Induces Focal Adhesion and Integrin Beta-1 Endocytosis

This study shows that canonical Wnt signaling induces endocytosis of focal adhesion proteins and integrin beta-1, affecting cell adhesion and signaling.

Non-lesional and Lesional Lupus Skin Share Inflammatory Phenotypes that Drive Activation of CD16+ Dendritic Cells

The paper compares non-lesional and lesional lupus skin to show they share inflammatory features that activate CD16+ dendritic cells.

PFKFB3 DEPLETION ACTIVATES β-CELL REPLICATION BY CELL COMPETITIVE CULLING OF COMPROMISED β-CELLS UNDER STRESS

This study shows that PFKFB3 depletion in β-cells under diabetogenic stress increases β-cell replication by removing damaged cells, improving β-cell function and mass.

Hibernation slows epigenetic aging in yellow-bellied marmots

This study examines how hibernation affects epigenetic aging in yellow-bellied marmots using epigenetic clocks and pacemakers, finding that aging slows during hibernation.

The intensity of the immune response to LPS and E. coli regulates the induction of preterm labor in Rhesus Macaques

This study shows that live E. coli induces stronger immune responses, including higher IL6 and prostaglandin levels, leading to preterm labor in Rhesus macaques compared to LPS.

Single Cell and Spatial Transcriptomics Defines the Cellular Architecture of the Antimicrobial Response Network in Human Leprosy Granulomas

The paper uses single cell and spatial transcriptomics to map the cellular architecture of antimicrobial responses in leprosy granulomas, identifying gene expression differences and spatial organization in reversal reactions.

Comparative Analysis of Embryo Proper and Suspensor Transcriptomes in Plant Embryos With Different Morphologies

The paper compares embryo proper and suspensor transcriptomes across plants with different suspensor morphologies, identifying shared and specific transcription factors involved in early embryo differentiation.

Cellular aging in vitro recapitulates multi-tissue epigenetic aging in vivo

This study shows that in vitro cellular aging models can reflect multi-tissue epigenetic aging in vivo, using DNAmCULTURE as a measure that tracks aging across tissues and responds to interventions.

Mechanism and inhibition of SARS-CoV-2 PLpro

This study investigates SARS-CoV-2 PLpro's mechanism and identifies non-covalent inhibitors with antiviral activity.

How prior pair-bonding experience affects future bonding behavior in monogamous prairie voles

This study investigates how prior pair-bonding experience in prairie voles affects future bonding behavior, finding that separation duration from the first partner influences the ability to form a new bond.

A disulfide constrains the ToxR periplasmic domain structure, altering its interactions with ToxS and bile-salts

This study shows that a disulfide bond in ToxR's periplasmic domain increases its affinity for ToxS and bile-salts, stabilizing its structure and function.

Impact of soil salinity on the cowpea nodule-microbiome and the isolation of halotolerant PGPR strains to promote plant growth under salinity stress

The paper examines how soil salinity affects cowpea nodule microbiomes and identifies halotolerant PGPR strains that enhance plant growth under salinity stress.

Phenotypic and functional characterization of corneal endothelial cells during in vitro expansion

This study compares two methods for expanding human corneal endothelial cells in vitro, finding that low mitogenic conditions better preserve cell identity and that senescence occurs with continuous passaging.

Molecular signatures for inflammation vary across cancer types and correlate significantly with tumor stage, gender and vital status of patients

The paper analyzes correlations between inflammatory molecular signatures and cancer types, finding significant associations with tumor stage, gender, and patient vital status in specific cancers.

The structure of a highly conserved picocyanobacterial protein reveals a Tudor domain with an RNA binding function

This study determines the structure of PSHCP, a highly conserved protein in cyanobacteria, revealing it contains a Tudor domain with RNA-binding activity, suggesting a role in translation.

Missense mutations in the MLKL brace region lead to lethal neonatal inflammation in mice and are present in high frequency in humans.

This study identifies a missense mutation in MLKL causing lethal neonatal inflammation in mice and links it to increased frequency in human autoinflammatory disease.

CHANGES OF TLQP-21 IN RESPONSE TO GLUCOSE LOAD

This study investigates how TLQP-21 levels change in mice after glucose load, showing increased plasma levels at 120 minutes and decreased pancreatic staining at 30 minutes.

Corneal Biomechanical Alterations in Patients with Chronic Ocular Graft Versus-host Disease

This study compares corneal biomechanics between patients with ocular graft-versus-host disease and healthy controls, finding reduced corneal hysteresis and resistance factor in oGVHD patients, with correlations between biomechanical parameters and disease severity and MMP-9 levels.

Seed Genome Hypomethylated Regions Are Enriched In Transcription Factor Genes

The paper identifies DNA Methylation Valleys (DMVs) in soybean and Arabidopsis seed genomes, showing they are enriched in transcription factor genes and remain hypomethylated throughout development.

Dual RNAseq of human leprosy lesions identifies bacterial determinants linked to host immune response

The paper uses dual RNAseq to analyze leprosy lesions, linking bacterial states to host immune responses through type I IFNs and antibody pathways.

A Phylogenomic Study Quantifies Competing Mechanisms for Pseudogenization in Prokaryotes

This study identifies two mechanisms for pseudogenization in prokaryotes using phylogenomic analysis of Mycobacterium leprae and other bacteria.

The Peach RGF/GLV Signalling Peptide pCTG134 Is Involved In A Regulatory Circuit That Sustains Auxin And Ethylene Actions

The paper investigates the role of the peach RGF/GLV peptide pCTG134 in an auxin-ethylene regulatory circuit, showing its involvement in root hair formation and hormonal crosstalk.