Author

S. Tudzarova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

F. Ma· 2 shared M. Pellegrini· 2 shared B. S. Seyran· 1 shared J. Min· 1 shared J. Shin· 1 shared K. H. Raval· 1 shared L. Salwinski· 1 shared L. Yang· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

F. Ma

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2 papers

Recent·Most cited

Dysfunctional β-cell longevity in diabetes relies on high energy conservation and positive epistasis

K. H. Raval, N. Jamshidi, B. S. Seyran, L. Salwinski, R. K. Pillai, L. Yang, F. Ma, M. Pellegrini, J. Shin, X. Yang, S. Tudzarova

The paper identifies PFKFB3-expressing dysfunctional β-cells in T2D, showing their survival via positive epistasis and reduced clearance, and demonstrates PFKFB3 inhibition restores glucose tolerance in mice.

bioRxiv · Mar 18, 2024Cell Biology

PFKFB3 DEPLETION ACTIVATES β-CELL REPLICATION BY CELL COMPETITIVE CULLING OF COMPROMISED β-CELLS UNDER STRESS

J. Min, F. Ma, M. Pellegrini, O. Greeff, S. Moncada, S. Tudzarova

This study shows that PFKFB3 depletion in β-cells under diabetogenic stress increases β-cell replication by removing damaged cells, improving β-cell function and mass.

bioRxiv · Apr 7, 2021 · PreprintCell Biology