Phonic Tics in a Rat Model of Tourette Syndrome Enable Research on Symptom-Based DBS
B. Sagalajev, L. Lennartz, N. Mokhtari, M. Szpak, T. Schüller, J. C. Baldermann, P. Andrade, V. Visser-Vandewalle, T. Sesia
This study shows that bicuculline-induced hyperkinesia and vocalizations in rats resemble motor and phonic tics, respectively, and respond to thalamic DBS.
bioRxiv · Aug 6, 2023 · PreprintAnimal Behavior & Cognition