Author

B. SRINIVASAN

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Athanasiadis· 2 shared K. Kus· 2 shared D. Barratt· 1 shared H. Lewis· 1 shared J. F. Mata· 1 shared L. E. T. Jansen· 1 shared L. Gabriel· 1 shared M.-J. Amorim· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

A. Athanasiadis

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3 papers

Recent·Most cited

Accelerating the Validation of Endogenous On-Target Engagement and In-cellulo Kinetic Assessment for Covalent Inhibitors of KRASG12C in Early Drug Discovery

V. Kantae, R. Polanski, H. Lewis, D. Barratt, B. SRINIVASAN

This paper develops a high-throughput targeted proteomics workflow using UPLC-MRM to assess on-target engagement of covalent inhibitors in cells, demonstrating its application with KRASG12C.

bioRxiv · Feb 17, 2022Biochemistry

Thermodynamic analysis of Zα domain-nucleic acid interactions

B. SRINIVASAN, K. Kus, A. Athanasiadis

The paper analyzes the thermodynamics of Z domain-nucleic acid interactions to understand binding mechanisms and differences between Z domains from different proteins.

bioRxiv · Jan 17, 2022Biochemistry

Enrichment of Zα domains at cytoplasmic stress granules is due to their innate ability to bind nucleic acids

L. Gabriel, B. Srinivasan, K. Kus, J. F. Mata, M.-J. Amorim, L. E. T. Jansen, A. Athanasiadis

The paper shows that Z domain-containing proteins localize to stress granules due to their nucleic acid binding ability, as demonstrated through protein interactions and stress granule enrichment experiments.

bioRxiv · Jan 20, 2021Biochemistry