Concurrent depletion of Vps37 proteins evokes ESCRT-I destabilization and profound cellular stress responses
K. Kolmus, P. Erdenebat, B. Stewig, E. Szymanska, K. Goryca, A. Szumera-Cieckiewicz, E. Dereziska-Wolek, M. Brewinska-Olchowik, K. Piwocka, M. Prochorec-Sobieszek, M. Mikula, M. Miaczynska
The paper shows that depletion of Vps37 proteins destabilizes ESCRT-I, leading to cell growth inhibition and sterile inflammation in colorectal cancer.
bioRxiv · Jul 2, 2020Cell Biology