M. Mikula

3D culture of pancreatic cancer cells in vitro recapitulates an aberrant mitochondrial oxidative phosphorylation genotype observed in vivo

This study shows that 3D cultures of pancreatic cancer cells better replicate the mitochondrial oxidative phosphorylation genotype seen in vivo compared to 2D cultures.

Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance

This study identifies liver sinusoidal endothelial cells as the primary cells responsible for hemoglobin clearance, revealing their role in heme detoxification and iron homeostasis through macropinocytosis and the BMP6-hepcidin axis.

Impaired iron recycling from erythrocytes is an early iron-dependent hallmark of aging

This study identifies impaired iron recycling by splenic red pulp macrophages as an early hallmark of aging and shows that reducing dietary iron improves iron turnover in aged mice.

The response network of HSP70 defines vulnerabilities in cancer cells with the inhibited proteasome

The paper identifies HSP70 as a vulnerability in cancer cells under proteasome inhibition, showing its role in suppressing drug effects and linking its expression to patient risk.

ESCRT-I controls lysosomal membrane protein homeostasis and restricts MCOLN1-dependent TFEB/TFE3 signaling.

This study shows ESCRT-I regulates lysosomal membrane protein homeostasis and modulates TFEB/TFE3 signaling through MCOLN1-dependent Ca2+ channels.

Concurrent depletion of Vps37 proteins evokes ESCRT-I destabilization and profound cellular stress responses

The paper shows that depletion of Vps37 proteins destabilizes ESCRT-I, leading to cell growth inhibition and sterile inflammation in colorectal cancer.

STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pigmentation pathway

This study shows that STAT3 promotes melanoma metastasis by repressing the MITF pigmentation pathway through CEBP induction.