M. Miaczynska

Ammonia inhibits antitumor activity of NK cells by decreasing mature perforin

This study shows ammonia reduces NK cell antitumor activity by decreasing mature perforin levels in the tumor microenvironment.

Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance

This study identifies liver sinusoidal endothelial cells as the primary cells responsible for hemoglobin clearance, revealing their role in heme detoxification and iron homeostasis through macropinocytosis and the BMP6-hepcidin axis.

The response network of HSP70 defines vulnerabilities in cancer cells with the inhibited proteasome

The paper identifies HSP70 as a vulnerability in cancer cells under proteasome inhibition, showing its role in suppressing drug effects and linking its expression to patient risk.

ESCRT-I controls lysosomal membrane protein homeostasis and restricts MCOLN1-dependent TFEB/TFE3 signaling.

This study shows ESCRT-I regulates lysosomal membrane protein homeostasis and modulates TFEB/TFE3 signaling through MCOLN1-dependent Ca2+ channels.

Concurrent depletion of Vps37 proteins evokes ESCRT-I destabilization and profound cellular stress responses

The paper shows that depletion of Vps37 proteins destabilizes ESCRT-I, leading to cell growth inhibition and sterile inflammation in colorectal cancer.

Splicing variation of BMP2K balances endocytosis, COPII trafficking and autophagy in erythroid cells

The paper identifies splicing variants of BMP2K that regulate erythroid differentiation by modulating COPII trafficking and autophagy through interactions with SEC16A.

GAS6-AXL signaling triggers actin remodeling and macropinocytosis that drive cancer cell invasion

This study identifies GAS6-AXL signaling as a driver of cancer cell invasion through actin remodeling and macropinocytosis in glioblastoma cells under glutamine-deprived conditions.