Germline-targeting chimpanzee SIV Envelopes induce V2-apex broadly neutralizing-like B cell precursors in a rhesus macaque infection model
R. Musharrafieh, Y. Safonova, G. Song, R. S. Roark, F.-H. Lee, S. Zhang, J. Hurtado, P. Yong, S. Wang, R. M. Russell, W. Ding, Y. Li, J. Rando, A. I. Murphy, E. Lindemuth, , R. Andrabi
This study shows that germline-targeting SCIVs can activate and expand B cells expressing V2-apex bnAb-like precursors in rhesus macaques.
bioRxiv · Sep 21, 2023 · PreprintImmunology