J. Hurtado

Unexpected delayed incursion of highly pathogenic avian influenza H5N1 (clade 2.3.4.4b) in the Antarctic region

The paper investigates the delayed incursion of H5N1 avian influenza in Antarctica by analyzing surveillance data from before confirmed cases.

Germline-targeting chimpanzee SIV Envelopes induce V2-apex broadly neutralizing-like B cell precursors in a rhesus macaque infection model

This study shows that germline-targeting SCIVs can activate and expand B cells expressing V2-apex bnAb-like precursors in rhesus macaques.

PERK-mediated antioxidant response is key for pathogen persistence in ticks

This study shows that the PERK pathway in ticks helps pathogens persist by enhancing an antioxidant response regulated by Nrf2.

Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple epitopes

The paper identifies two broadly neutralizing antibodies against coronaviruses by screening B cell repertoires, showing they target different epitopes and offer protection against variants.

Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies

The paper structures and characterizes Lassa virus glycoproteins from multiple lineages and identifies neutralizing antibodies that target conserved epitopes.

Efficient isolation of rare B cells using next-generation antigen barcoding

This paper introduces a method for efficiently isolating rare antigen-specific B cells using next-generation antigen barcoding and a computational framework, demonstrating its ability to recover thousands of mAbs, including rare HIV broadly neutralizing antibodies.

Propagation of seminal toxins through binary expression gene drives can suppress polyandrous populations

This paper proposes a gene drive system using binary expression to spread dominant lethal alleles and suppress polyandrous populations by engineering seminal proteins that kill females.

The unfolded protein response triggers the immune deficiency pathway in ticks

The study shows that the unfolded protein response (UPR) initiates the immune deficiency (IMD) pathway in ticks, linking ER stress to pathogen restriction.

Research gaps and new insights in the intriguing evolution of Drosophila seminal proteins

This study examines the evolution of Drosophila seminal proteins by analyzing genomic data from multiple species and identifies gene co-option as a common mechanism for their origin.

Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model

This study rapidly identifies potent SARS-CoV-2 neutralizing antibodies and demonstrates their protective efficacy in an animal model.

What does mitogenomics tell us about the evolutionary history of the Drosophila buzzatii cluster (repleta group)

This study assembles six mitogenomes from five Drosophila buzzatii cluster species to investigate their phylogenetic relationships and divergence times, finding support for monophyly and two main clades.

Combinatorial Drug Discovery in Nanoliter Droplets

This paper develops a high-throughput screening system for discovering synergistic drug combinations and applies it to identify new antibiotic synergies against E. coli.