Author

R. S. Roark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:rat· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Organism:mouse· 2 Assay:CITE-seq· 1

Frequent Co-Authors

E. Lindemuth· 4 shared H. Li· 4 shared J. Rando· 4 shared M. G. Lewis· 4 shared S. Wang· 4 shared A. I. Murphy· 3 shared B. H. Hahn· 3 shared C. Zhao· 3 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

E. Lindemuth

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Author profile →

4 papers

Recent·Most cited

Germline-targeting chimpanzee SIV Envelopes induce V2-apex broadly neutralizing-like B cell precursors in a rhesus macaque infection model

R. Musharrafieh, Y. Safonova, G. Song, R. S. Roark, F.-H. Lee, S. Zhang, J. Hurtado, P. Yong, S. Wang, R. M. Russell, W. Ding, Y. Li, J. Rando, A. I. Murphy, E. Lindemuth, , R. Andrabi

This study shows that germline-targeting SCIVs can activate and expand B cells expressing V2-apex bnAb-like precursors in rhesus macaques.

bioRxiv · Sep 21, 2023 · PreprintImmunology

A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies

F. Bibollet-Ruche, R. M. Russell, W. Ding, W. Liu, Y. Li, K. Wagh, D. Wrapp, R. Habib, A. N. Skelly, R. S. Roark, S. Sherrill-Mix, S. Wang, J. Rando, E. Lindemuth, K. Cruickshank, , B. H. Hahn

This study identifies a new class of V2-directed cross-neutralizing antibodies targeting a cryptic epitope in occluded-open HIV and SIV Env trimers.

bioRxiv · Oct 18, 2022Immunology

New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure

H. Li, S. Wang, F.-H. Lee, R. S. Roark, A. I. Murphy, J. Smith, C. Zhao, J. Rando, N. Chohan, Y. Ding, E. Kim, E. Lindemuth, K. J. Bar, I. Pandrea, C. Apetrei, , G. M. Shaw

This paper demonstrates that SHIVs with bulky aromatic amino acid substitutions at Env375 replicate efficiently in rhesus macaques and can be used for preclinical HIV vaccine testing.

bioRxiv · Jan 13, 2021Microbiology

Recapitulation of HIV-1 Env-Antibody Coevolution in Macaques Leading to Neutralization Breadth

R. S. Roark, H. Li, W. B. Williams, H. Chug, R. D. Mason, J. Gorman, S. Wang, F.-H. Lee, J. Rando, M. Bonsignori, K.-K. Hwang, K. O. Saunders, K. Wiehe, M. A. Moody, P. T. Hraber, , C. A Schramm

Virus-antibody coevolution in rhesus macaques recapitulates developmental features of human antibodies.

bioRxiv · Aug 5, 2020Immunology