Effect of Positive Allosteric Modulation and Orthosteric Agonism of Dopamine D2 Receptors on Respiration in Mouse Models of Rett Syndrome
S. N. Maletz, B. T. Reid, D. M. Baekey, J. R. Whitaker-Fornek, J. T. Bateman, J. M. Bissonnette, E. S. Levitt
This study evaluates the effects of D2 receptor modulation on respiration in Rett syndrome mouse models, finding that orthosteric agonism improves breathing while positive allosteric modulation does not.
bioRxiv · Apr 13, 2022 · PreprintPharmacology & Toxicology