Author

B. van der Sanden

Radboud University Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioinformatics· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Alexander HoischeniD· 2 shared Aaron R. QuinlaniD· 1 shared Andrew J. SharpiD· 1 shared Arianna TucciiD· 1 shared B. Jadhav· 1 shared Brent S. PederseniD· 1 shared C. Betz· 1 shared C.F.H.A. Gilissen· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenetic & Genomic Medicine

Alexander HoischenORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

HiFi sequencing accurately identifies clinically relevant variants in paralogous genes

B. van der Sanden, C. Betz, K. Herzog, Esther Schamschula, K. Wimmer, Ira Vater, S. Balachandran, Jordi Corominas, Raoul Timmermans, Ronny C. Derks, M. Spielmann, MA Eberle, C.F.H.A. Gilissen, L.E.L.M. Vissers, Johannes Zschocke, , Alexander Hoischen

This study shows that PacBio HiFi long-read sequencing with Paraphase variant caller detects all clinically relevant variants in paralogous regions, improving variant calling accuracy.

The American Journal of Human Genetics · Jun 1, 2026Peer-reviewedGenetic & Genomic Medicine

TRGT-denovo: accurate detection of de novo tandem repeat mutations

Tom Mokveld, Egor Dolzhenko, Harriet Dashnow, T. J. Nicholas, Thomas A. Sasani, B. van der Sanden, B. Jadhav, Brent S. Pedersen, Zev N. Kronenberg, Arianna Tucci, Andrew J. Sharp, Aaron R. Quinlan, Christian Gilissen, Alexander Hoischen, Michael A. Eberle

TRGT-denovo accurately detects de novo tandem repeat mutations in family trios, reducing false positives and improving precision compared to genotype-based methods.

bioRxiv · Jul 16, 2024 · PreprintBioinformatics