Probing molecular specificity with deep sequencing and biophysically interpretable machine learning
H. Tomas Rube, Chaitanya Rastogi, Siqian Feng, Judith F. Kribelbauer-Swietek, Allyson Li, Basheer Becerra, Lucas A. N. Melo, Bach Viet, Xiaoting Li, Hammaad Adam, Neel H. Shah, Richard S. Mann, Harmen J. Bussemaker
The paper introduces ProBound, a machine learning framework that quantifies biophysical parameters of protein-ligand interactions using NGS data, and couples it with Kd-seq to determine absolute affinities.
Nature Biotechnology · May 23, 2022Peer-reviewedGenomics