Siqian Feng

FETCH enables precise fluorescent labeling of membrane proteins in Drosophila with spatiotemporal control through covalent bond formation.

The paper shows Hox paralogs use different cofactors in distinct domains to activate specific gene regulatory networks in Drosophila legs.

SpyChIP identifies cell type-specific transcription factor binding in complex tissues without dissociation, revealing Ubx-DNA interactions in Drosophila haltere disc cells.

The paper introduces ProBound, a machine learning framework that quantifies biophysical parameters of protein-ligand interactions using NGS data, and couples it with Kd-seq to determine absolute affinities.

This paper describes a scarless genome editing method for Drosophila using site-specific integrases and homing nucleases, enabling efficient modification near landing sites.

The paper investigates how DNA sequence influences the formation of transcription factor complexes and shows that non-canonical binding sites arise from direct interactions with functionally bound sites.