Dietary Serine Restriction Impacts H3K27 and H3K4 Methyl Epigenomes to Impede Head and Neck Cancer Cell Plasticity and Tumor Growth
Stacy Jankowski, Lina Kroehling, Emily R. Fisher, Nina C. Hardy, Bach-Cuc Nguyen, Manish V. Bais, Xaralabos Varelas, Stefano Monti, Maria A. Kukuruzinska
This study shows that dietary serine restriction alters H3K27me3 and H3K4me3 histone modifications, reducing tumor growth and plasticity in head and neck cancer.
bioRxiv · Oct 21, 2025 · PreprintCancer Biology